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 List – 65 Drug Patents that are Expiring in 2025

List – 65 Drug Patents that are Expiring in 2025

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Xalkori
Crizotinib

Sales:
$524 Million (2018)

PatentsExpiration Date
US8785632March 01, 2025
US7230098August 26, 2025
US7858643October 8, 2029
US8217057November 6, 2029

Dosage: Capsule; Oral
Company: Pfizer
Ingredients: Crizotinib
Treatment: Non-Small Cell Lung Carcinoma

Omegaven
Fish Oil Triglycerides

Sales:
–

PatentsExpiration Date
US9566260July 11, 2025
US9629821July 11, 2025
US10350186November 05, 2024

Dosage: Emulsion; Intravenous
Company: Fresenius Kabi USA LLC
Ingredients: Fish Oil Triglycerides
Treatment: Parenteral Nutrition-Associated Cholestasis (PNAC)

Yupelri
Revefenacin

Sales:
$3.3 Million (Q4, 2018)

PatentsExpiration Date
US7491736March 10, 2025
US7521041March 10, 2025
US7550595March 10, 2025
US7585879March 10, 2025
US7910608March 10, 2025
US7288657December 23, 2025
US10550081July 14, 2030
US9765028July 14, 2030
US8541451August 25, 2031

Dosage: Solution; Inhalation
Company: Mylan Ireland Ltd
Ingredients: Revefenacin
Treatment: Chronic Obstructive Pulmonary Disease

Sprycel
Dasatinib

Sales:
$477 Million (2019)

PatentsExpiration Date
US7417148December 11, 2025
US7767678November 23, 2026
US7919625December 11, 2025

Dosage: Tablet; Oral
Company: PF Prism CV
Ingredients: Bosutinib Monohydrate
Treatment: Chronic Phase Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

Bosulif
Bosutinib Monohydrate

Sales:
$2 Billion (2018)

PatentsExpiration Date
US8680103February 04, 2025

Dosage: Tablet; Oral
Company: Bristol Myers Squibb Co
Ingredients: Dasatinib
Treatment: Chronic Myeloid Leukemia (CML), Acute Lymphoblastic Leukemia (ALL)

Cresemba
Isavuconazonium Sulfate

Sales:
$180 Million (Jul 2018 – Jun 2019)

PatentsExpiration Date
US6812238October 31, 2025

Dosage: Capsule; Oral
Company: Astellas Pharma US Inc
Ingredients: Isavuconazonium Sulfate
Treatment: Invasive Aspergillosis And Mucormycosis

Lysteda
Tranexamic Acid

Sales:
$70 Million (2008)

PatentsExpiration Date
US8026281April 22, 2025

Dosage: Capsule; Oral
Company: Lupin Inc
Ingredients: Fenofibrate
Treatment: High Cholesterol and Triglycerides (fatty acids) in Blood

Antara
Fenofibrate

Sales:
$70 Million (2008)

PatentsExpiration Date
US8026281April 22, 2025

Dosage: Capsule; Oral
Company: Lupin Inc
Ingredients: Fenofibrate
Treatment: High Cholesterol and Triglycerides (fatty acids) in Blood

Lysteda
Tranexamic Acid

Sales:
$25 Million (2012)

PatentsExpiration Date
US7947739March 04, 2025
US8022106March 04, 2025
US8273795March 04, 2025
US8487005March 04, 2025
US8791160March 04, 2025
US8809394March 04, 2025
US8957113March 04, 2025
US9060939March 04, 2025

Dosage: Tablet; Oral
Company: Amring Pharmaceuticals Inc
Ingredients: Tranexamic Acid
Treatment: Cyclic Heavy Menstrual Bleeding

Bepreve
Bepotastine Besilate

Sales:
$160.3 Million (2011)

PatentsExpiration Date
US8784789January 13, 2025
US8877168July 30, 2023

Dosage: Solution/Drops; Ophthalmic
Company: Bausch And Lomb Inc
Ingredients: Bepotastine Besilate
Treatment: Itching of the Eyes due to Allergies

Sancuso
Granisetron

Sales:
$20 – $25 Million

PatentsExpiration Date
US7608282January 22, 2025

Dosage: Film, Extended Release; Transdermal
Company: Kyowa Kirin Inc
Ingredients: Granisetron
Treatment: Nausea and Vomiting Caused by Cancer Chemotherapy

Nucynta
Tapentadol Hydrochloride

Sales:
$46.8 Million (2019)

PatentsExpiration Date
US7994364June 27, 2025

Dosage: Tablet; Oral
Company: Collegium Pharmaceuticals Inc
Ingredients: Tapentadol Hydrochloride
Treatment: Moderate to Severe Pain

Nexlizet
Bempedoic Acid, Ezetimibe

Sales:
–

PatentsExpiration Date
US7335799December 03, 2025

Dosage: Tablet; Oral
Company: Esperion Therapeutics Inc
Ingredients: Bempedoic Acid, Ezetimibe
Treatment: Reduce the Amount of Cholesterol and other Fatty Substances in Blood

Vyzulta
Latanoprostene Bunod

Sales:
–

PatentsExpiration Date
US8058467January 5, 2025
US7910767January 5, 2025
US7273946October 3, 2025

Dosage: Eye Drops
Company: Bausch & Lomb
Ingredients: LATANOPROSTENE BUNOD
Treatment: Intraocular Pressure in Patients with Open-angle Glaucoma or Ocular Hypertension

Trilipix
Fenofibrate

Sales:
–

PatentsExpiration Date
US7259186January 7, 2025

Dosage: Oral
Company: AbbVie Inc
Ingredients: CHOLINE FENOFIBRATE
Treatment: Abnormal Blood Lipid Levels

Duaklir
Aclidinium bromide/formoterol

Sales:
–

PatentsExpiration Date
USRE46417February 10, 2025

Dosage: Inhalation
Company: ALMIRALL, S.A
Ingredients: ACLIDINIUM BROMIDE; FORMOTEROL FUMARATE
Treatment: Chronic Obstructive Pulmonary Disease (COPD)

Arcapta
Indacaterol

Sales:
–

PatentsExpiration Date
US6878721February 25, 2025

Dosage: Inhalation
Company: Novartis
Ingredients: INDACATEROL MALEATE
Treatment: Chronic Obstructive Pulmonary Disease (COPD)

Rukobia
Fostemsavir

Sales:
–

PatentsExpiration Date
US8461333February 25, 2025
US7745625November 19, 2027

Dosage: Oral
Company: ViiV Healthcare
Ingredients: FOSTEMSAVIR TROMETHAMINE
Treatment: HIV/AIDS

Incivek
Telaprevir

Sales:
–

PatentsExpiration Date
US7820671February 25, 2025

Dosage: Oral
Company: Johnson & Johnson
Ingredients: TELAPREVIR
Treatment: Hepatitis C

Viberzi
Eluxadoline

Sales:
–

PatentsExpiration Date
US10213415March 14, 2025
US8609709March 14, 2025
US7786158March 14, 2025
US9115091July 7, 2028
US8691860July 7, 2028
US7741356May 27, 2029

Dosage: Oral
Company: Allergan
Ingredients: ELUXADOLINE
Treatment: Diarrhea and Abdominal Pain

Glucophage
Metformin

Sales:
–

PatentsExpiration Date
US7780987March 23, 2025

Dosage: Oral
Company: Merck & Co
Ingredients: METFORMIN HYDROCHLORIDE
Treatment: Type 2 Diabetes

Roxicodone
Oxycodone

Sales:
–

PatentsExpiration Date
US10696684March 30, 2025
US10407434March 30, 2025
US9522919March 30, 2025
US9073933March 30, 2025

Dosage: Oral, Sublingual, Intramuscular, Intravenous, Intranasal, Subcutaneous, Transdermal, Rectal, Epidural
Company: Xanodyne Pharmaceuticals
Ingredients: OXYCODONE HYDROCHLORIDE
Treatment: Moderate to Severe Pain

Tegsedi
Inotersen

Sales:
–

PatentsExpiration Date
US8101743April 1, 2025
US9061044April 29, 2031

Dosage: Subcutaneous injection
Company: Akcea Therapeutics, Inc.
Ingredients: INOTERSEN SODIUM
Treatment: Nerve Damage in adults with Hereditary transthyretin-mediated Amyloidosis

Reyvow
Lasmiditan

Sales:
–

PatentsExpiration Date
US7423050April 6, 2025
US11053214December 5, 2037

Dosage: Oral, Intravenous
Company: Eli Lilly and Company
Ingredients: LASMIDITAN SUCCINATE
Treatment: Migraine with or without Aura

Kyprolis
Carfilzomib

Sales:
$1.06 Billion (2020)

PatentsExpiration Date
US8207125April 14, 2025
US7232818April 14, 2025
US8207297April 14, 2025
US7417042July 20, 2026

Dosage: Intravenous
Company: Amgen Inc.
Ingredients: CARFILZOMIB
Treatment: Relapsed or Refractory Multiple Myeloma

Biktarvy
Bictegravir/emtricitabine/tenofovir alafenamide

Sales:
–

PatentsExpiration Date
US7390791April 17, 2025
US9296769August 15, 2032
US8754065August 15, 2032
US9216996December 19, 2033
US9732092December 19, 2033
US9708342June 19, 2035

Dosage: Oral
Company: Gilead Sciences
Ingredients: BICTEGRAVIR SODIUM; EMTRICITABINE; TENOFOVIR ALAFENAMIDE FUMARATE
Treatment: HIV/AIDS

Stendra
Avanafil

Sales:
–

PatentsExpiration Date
US6656935April 27, 2025

Dosage: Oral
Company: Vivus Inc.
Ingredients: AVANAFIL
Treatment: Erectile Dysfunction

Inlyta
Axitinib

Sales:
$93 Million (2020)

PatentsExpiration Date
US6534524April 29, 2025
US8791140December 14, 2030

Dosage: Oral
Company: Pfizer
Ingredients: AXITINIB
Treatment: Renal Cell Carcinoma

Camptosar
Irinotecan

Sales:
–

PatentsExpiration Date
US9782349May 2, 2025
US9724303May 2, 2025
US8992970May 2, 2025
US10722508May 2, 2025
US8329213January 6, 2027
US8147867August 29, 2028

Dosage: Intravenous
Company: Pfizer
Ingredients: IRINOTECAN HYDROCHLORIDE
Treatment: Colon Cancer and Small Cell Lung Cancer

Jentadueto
Linagliptin/metformin hydrochloride

Sales:
–

PatentsExpiration Date
US7407955May 2, 2025

Dosage: Oral
Company: Boehringer Ingelheim
Ingredients: LINAGLIPTIN; METFORMIN HYDROCHLORIDE
Treatment: High Blood Sugar Levels caused by Type 2 Diabetes

Pexeva
Paroxetine mesylate

Sales:
–

PatentsExpiration Date
US7598271May 4, 2025
US8946251August 4, 2026
US8658663April 6, 2029

Dosage: Oral
Company: Sebela Pharmaceutical
Ingredients: PAROXETINE MESYLATE
Treatment: Symptoms of Menopause

Doptelet
Avatrombopag

Sales:
–

PatentsExpiration Date
US7638536May 5, 2025

Dosage: Oral
Company: AkaRx, Inc.
Ingredients: AVATROMBOPAG MALEATE
Treatment: Thrombocytopenia Associated with Chronic Liver Disease

Lymphoseek
Technetium Tc 99m tilmanocept

Sales:
–

PatentsExpiration Date
US6409990May 12, 2025
US9439985September 27, 2033

Dosage: Subcutaneous injection
Company: Navidea Biopharmaceuticals
Ingredients: TECHNETIUM TC-99M TILMANOCEPT
Treatment: Identify Sentinel Lymph Nodes

Olysio
Simeprevir

Sales:
–

PatentsExpiration Date
US7671032May 19, 2025
US8349869July 28, 2026
US8754106July 28, 2026
US8741926July 28, 2026
US9040562July 28, 2026
US9856265July 28, 2026
US8148399September 5, 2029

Dosage: Oral
Company: Johnson & Johnson
Ingredients: SIMEPREVIR SODIUM
Treatment: Hepatitis C

Edarbi
Azilsartan

Sales:
–

PatentsExpiration Date
US7157584May 22, 2025

Dosage: Oral
Company: Takeda Pharmaceutical
Ingredients: AZILSARTAN KAMEDOXOMIL
Treatment: Hypertension

Onpattro
Patisiran

Sales:
–

PatentsExpiration Date
US8334373May 27, 2025
US8168775October 20, 2029
US10240152October 20, 2029
US11079379August 27, 2035

Dosage: Intravenous
Company: Alnylam Pharmaceuticals
Ingredients: PATISIRAN SODIUM
Treatment: Polyneuropathy in People with Hereditary transthyretin-mediated Amyloidosis

Diprivan
Propofol

Sales:
–

PatentsExpiration Date
US8476010June 1, 2025

Dosage: Intravenous
Company: Fresenius Kabi
Ingredients: PROPOFOL
Treatment: Used to help Patients Relax before and during General Anesthesia for Surgery

Kazano
Alogliptin/metformin

Sales:
–

PatentsExpiration Date
US8288539June 24, 2025
US7807689June 27, 2028

Dosage: Oral
Company: Takeda Pharmaceuticals
Ingredients: ALOGLIPTIN BENZOATE; METFORMIN HYDROCHLORIDE
Treatment: Blood Sugar Control in Adults with Type 2 Diabetes

Amondys 45
Casimersen

Sales:
–

PatentsExpiration Date
US9447415June 28, 2025
US8524880April 2, 2026
US10287586November 12, 2030
US9228187November 12, 2030

Dosage: Intravenous
Company: Sarepta Therapeutics, Inc.
Ingredients: CASIMERSEN
Treatment: Duchenne Muscular Dystrophy (DMD)

Exondys 51
Eteplirsen

Sales:
–

PatentsExpiration Date
US10781451June 28, 2025
US9018368June 28, 2025
US9243245October 27, 2028

Dosage: Intravenous
Company: Sarepta Therapeutics, Inc.
Ingredients: ETEPLIRSEN
Treatment: Duchenne Muscular Dystrophy (DMD)

Vyondys 53
Golodirsen

Sales:
–

PatentsExpiration Date
US10227590June 28, 2025
US9994851June 28, 2025
US9024007June 28, 2025
US10968450June 28, 2025
US10421966June 28, 2025

Dosage: Intravenous
Company: Sarepta Therapeutics, Inc.
Ingredients: GOLODIRSEN
Treatment: Duchenne Muscular Dystrophy (DMD)

Vyleesi
Bremelanotide

Sales:
–

PatentsExpiration Date
US6794489June 28, 2025

Dosage: Subcutaneous
Company: Palatin Technologies
Ingredients: BREMELANOTIDE ACETATE
Treatment: Low Sexual Desire in Women

Zydelig
Idelalisib

Sales:
–

PatentsExpiration Date
USRE44638August 5, 2025
US8865730March 5, 2033
US10730879March 5, 2033
US9469643September 2, 2033

Dosage: Oral
Company: Gilead Sciences
Ingredients: IDELALISIB
Treatment: Blood Cancer

Duzallo
Lesinurad/Allopurinol

Sales:
–

PatentsExpiration Date
US8003681August 25, 2025
US8546436February 29, 2032

Dosage: Oral
Company: AstraZeneca
Ingredients: ALLOPURINOL; LESINURAD
Treatment: Gout

Prolensa
Bromfenac

Sales:
–

PatentsExpiration Date
US8129431September 11, 2025

Dosage: Eye Drops
Company: Bausch & Lomb
Ingredients: BROMFENAC SODIUM
Treatment: Ocular Inflammation and Pain after Cataract Surgery

Nuplazid
Pimavanserin

Sales:
–

PatentsExpiration Date
US7923564September 26, 2025
US7732615June 3, 2028
US7601740April 29, 2030

Dosage: Oral
Company: Acadia Pharmaceuticals
Ingredients: PIMAVANSERIN TARTRATE
Treatment: Parkinson’s disease psychosis

Baxdela
Delafloxacin

Sales:
–

PatentsExpiration Date
US9539250October 7, 2025
US8273892August 6, 2026
US7728143November 20, 2027
US8871938September 23, 2029
USRE46617December 28, 2029

Dosage: Oral, Intravenous
Company: Melinta Therapeutics
Ingredients: DELAFLOXACIN MEGLUMINE
Treatment: Acute Bacterial Skin and Skin Structure Infections

Lenvima
Lenvatinib

Sales:
–

PatentsExpiration Date
US7253286October 24, 2025
US7612208September 19, 2026
US11186547August 26, 2035
US10407393August 26, 2035
US10259791August 26, 2035

Dosage: Oral
Company: Eisai Inc
Ingredients: LENVATINIB MESYLATE
Treatment: Thyroid Cancer

Cresemba
Isavuconazole

Sales:
–

PatentsExpiration Date
US6812238October 31, 2025

Dosage: Oral, Intravenous
Company: Astellas Pharma
Ingredients: ISAVUCONAZONIUM SULFATE
Treatment: Aspergillosis and Mucormycosis

Lybalvi
Olanzapine/samidorphan

Sales:
–

PatentsExpiration Date
US7262298November 23, 2025
US9119848August 30, 2031

Dosage: Oral
Company: Alkermes, Inc
Ingredients: OLANZAPINE; SAMIDORPHAN L-MALATE
Treatment: Schizophrenia and Bipolar Disorder

Opsumit
Macitentan

Sales:
–

PatentsExpiration Date
US7094781December 5, 2025

Dosage: Oral
Company: Actelion Pharmaceuticals
Ingredients: MACITENTAN
Treatment: Pulmonary Arterial Hypertension

Latuda
Lurasidone

Sales:
–

PatentsExpiration Date
USRE45573December 23, 2025

Dosage: Oral
Company: Sunovion Pharmaceuticals
Ingredients: LURASIDONE HYDROCHLORIDE
Treatment: Schizophrenia and Bipolar Disorder

Klisyri
Tirbanibulin

Sales:
–

PatentsExpiration Date
US8980890December 28, 2025
US8236799December 28, 2025
US7300931February 6, 2026
US7851470February 2, 2029
US10669236September 7, 2038

Dosage: Topical
Company: Almirall, LLC.
Ingredients: TIRBANIBULIN
Treatment: Actinic Keratosis

Signifor
Pasireotide

Sales:
–

PatentsExpiration Date
US8299209December 27, 2025
US7473761December 14, 2026

Dosage: Subcutaneous Injection, Intramuscular Injection
Company: Recordati Rare Diseases Inc.
Ingredients: PASIREOTIDE DIASPARTATE
Treatment: Cushing’s Disease

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