5 Startups developing Medical Devices with Nanotechnology

The medical industry faces several challenges that can be addressed by nanotechnology. Traditional methods often result in therapeutics distributed throughout the body, not just the target site. This leads to reduced efficacy and potential side effects. Furthermore, current diagnostic methods can be invasive and expensive and may not detect diseases until they have progressed to a late stage.

Nanomedicines, on the other hand, encapsulate therapeutic compounds in submicrometer-sized carriers, allowing more efficient delivery to the target site. They enhance therapeutic efficacy and minimize accumulation in healthy body sites to reduce toxicity.

Nanoencapsulation can also protect therapeutics from degradation in biological environments and provide solubilization. Nanotechnology can contribute to developing rapid diagnostic tests and more precise imaging techniques for disease diagnosis.

This article discusses five innovative startups implementing nanotechnology in medical devices in 2024.

1. Nanotransfer

Founding Year	2021
Headquarters	California, United States
Total Funding Amount	$200K
Last Funding Round/Amount	Pre-Seed/$200K
Website	https://www.gridexponential.com/startups/nanotransfer

Nanotransfer is a biotechnology startup that develops nanotechnology-based gene delivery systems. Their main product is a ready-to-use, biocompatible, and efficient delivery system for gene therapy.

Their delivery systems can transport different types of nucleic acids to treat genetic disorders and abnormalities. Their therapies are non-immunogenic and safe. This versatility makes them ideal for delivering a wide range of genetic material to cells, setting Nanotransfer apart from other startups in the industry.

Its CEO, Carla Giacomelli, has a strong background in interfacial physical chemistry, nano-science, and biophysics. She holds a Ph.D. in chemistry from the National University of Cordoba.

Nanotransfer has raised a total of $200K in funding. This was a Pre-Seed round raised on Dec 25, 2021.

2. OncoRevive

Founding Year	2023
Headquarters	Brunswick, Australia
Total Funding Amount	$144K
Last Funding Round/Amount	Seed/$144K
Website	linkedin.com/company/oncorevive

OncoRevive develops a nanotechnology-based liquid biopsy designed to identify cancer at its early stages. The startup’s platform offers cancer-detection options by examining protein, gene, and glycan biomarkers. 

This enables health practitioners to get an accurate and comprehensive analysis of tumor biology for personalized medicine.

OncoRevive has raised a total of A$225K in funding. This was a Pre-Seed round raised on Nov 17, 2023.

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3. DNA Nanobots

Founding Year	2021
Headquarters	Ohio, United States
Total Funding Amount	Not available
Last Funding Round/Amount	Not available
Website	dnananobots.com

DNA Nanobots is a biotech startup that develops DNA-based nanodevices (nanobots) for biomedical applications. It specializes in crafting targeted therapeutics delivery using its DNA nanoparticle platform.

The startup uses its IP to create products for targeted chemotherapies, vaccines, point-of-care diagnostics, and functionalized gene delivery. They even offer consultation to other companies to assemble complex and highly precise DNA nanobots.

Its CEO, Jeff Spitzner, has 20 years of experience as a founder and executive of nine life sciences and biotechnology startups. He has a Ph.D. in molecular genetics from Ohio State University.

DNA Nanobots has raised funding from a pre-seed round on Jan 24, 2024. The amount is undisclosed.

4. Avisi Technologies

Founding Year	2017
Headquarters	California, United States
Total Funding Amount	$7.5M
Last Funding Round/Amount	Seed/$4.06M
Website	avisitech.com

Avisi Technologies develops a nanotechnology-enabled ocular implant to stop blindness in glaucoma patients. Its main product is VisiPlate, an aqueous shunt designed to treat glaucoma. VisiPlate lowers intraocular pressure in patients with open-angle glaucoma. It is 20 times thinner than human hair and made of alumina, making it long-lasting and decreasing procedure time.

This approach helps remove excess fluid inside the eye, relieving high pressures that damage the optic nerve and cause open-angle glaucoma.

Its CEO, Rui Jing, is an economics graduate from The Wharton School. She has seven years of entrepreneurial experience with startups.

Avisi Technologies has raised a total of $10.2M in funding. Their latest funding came from a Seed round on October 1, 2023.

5. Nanoligent

Founding Year	2017
Headquarters	Barcelona, Spain
Total Funding Amount	€2.8M
Last Funding Round/Amount	Seed round/€1.8M
Website	www.nanoligent.com

Nanoligent is a biotech startup that is dedicated to drug design and the development of targeted therapeutic biologics. 

Its technology allows the design of new proteins organized as nanoparticles, capable of targeting specific biological systems. This protein architecture is highly stable upon administration in living cells, allowing long-lasting systemic circulation and site-specific drug delivery. 

These proteins can self-assemble and form nanoparticles that avoid kidney clearance, thereby delivering the desired payload selectively. For instance, this technique can transport a chemotherapeutic drug, release it only to cancer cells, and reduce collateral damage to the patient.

Montserrat Cano Biosca, CEO of Nanoligent, has extensive experience in the Biotech and Pharma sector. She has worked on several preclinical and clinical projects during the last 20 years.

Nanoligent has raised a total of €2.8M in funding. Their latest funding came from a Seed round on September 27, 2022.

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Authored By – Hemanth Shenoy, Market Research